| 5 Nov | Quincy 52 | at | SIUE 61 | vs ND1 | ||
| 8 Nov | SIUE 60 | at | Iowa 87 | at B10 | ||
| 12 Nov | Valparaiso 89 | at | SIUE 76 | vs MVC | ||
| 16 Nov | SIUE 57 | at | Incarnate Word 55 | at SLC | ||
| 18 Nov | SIUE 56 | at | South Dakota 71 | at SL | ||
| 23 Nov | N Illinois 68 | at | SIUE 64 | vs MAC | ||
| 26 Nov | SIUE 50 | at | Pacific 78 | at WCC | ||
| 29 Nov | SIUE 51 | at | UC Riverside 69 | at BWC | ||
| 4 Dec | Chicago St 89 | at | SIUE 81 | vs WAC | ||
| 15 Dec | SIUE 54 | at | Northwestern 72 | at B10 | ||
| 17 Dec | SIUE 73 | at | Winthrop 93 | at BSo | ||
| 21 Dec | SIUE 55 | at | Detroit 81 | at HL | ||
| 29 Dec | Lindenwood-Belle 48 | at | SIUE 96 | vs ND1 | ||
| 2 Jan | SIUE 79 | at | Belmont 69 | |||
| 4 Jan | SIUE 74 | at | Tennessee St 79 | |||
| 9 Jan | SIUE 77 | at | Morehead St 83 | |||
| 11 Jan | SIUE 72 | at | E Kentucky 78 | |||
| 16 Jan | Tennessee Tech 72 | at | SIUE 69 | |||
| 18 Jan | Jacksonville St | at | SIUE | |||
| 23 Jan | SE Missouri St | at | SIUE | |||
| 25 Jan | TN Martin | at | SIUE | |||
| 30 Jan | SIUE | at | Austin Peay | |||
| 1 Feb | SIUE | at | Murray St | |||
| 6 Feb | Morehead St | at | SIUE | |||
| 8 Feb | E Kentucky | at | SIUE | |||
| 13 Feb | SIUE | at | E Illinois | |||
| 15 Feb | SIUE | at | SE Missouri St | |||
| 20 Feb | Austin Peay | at | SIUE | |||
| 22 Feb | Murray St | at | SIUE | |||
| 27 Feb | SIUE | at | TN Martin | |||
| 29 Feb | E Illinois | at | SIUE |
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